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0.4% with placebo and 1.1% with dulaglutide [24]
Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver)
However there is no established safety profile for GLP-1 in pregnancy and experts recommend discontinuing 1-2 months before conception
Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism
The medication works by targeting key receptors in the body that regulate both glucose metabolism and hunger signals
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